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KMID : 0364019920250090962
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Korean Journal of Thoracic and Cardiovascular Surgery
1992 Volume.25 No. 9 p.962 ~ p.967
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Surgical Treatment of Stage III Carcinoma of the Lung after Preoperative Chemotherapy and Radiation Therapy -3 Cases Report-
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이두연
주석중/김해균/김상진/김형중
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Abstract
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Eight patients with proven clinical stage III lung carcinoma of which six were epidermoid cell carcinoma and two were small cell carcinoma underwent concomitant radiation therapy and chemotherapy before surgical resection from March 1990 to
February
1992 at the thoracic surgical department, Yongdong Severance Hospital, Yonsei University College Medicine.
The therapy consisted of more than one cycle of chemotherapy every 4 weeks and concomitant irradiation.
Three to four weeks after chemotherapy and radiation therapy, the patients were reevaluated for thoracotomy and pulmonary resection.
Two patients were found to have unresectable lesions and, radiosotopes were implanted to the remaining tumors. Three patients had complete pneumonectomies and two patients had pericardial penumonectomyo.
Only one patients had complete pneumonectomy & concomitant of ribs attached to tumors with reconstruction of chest wall with Marlex mesh.
Complete sterilization of lung tumor and mediastinal nodes proven histologically was achieved in 2 patients, without operative mortality.
The median survival of all patients was eight months, but the median survival of survivors which lung tumor were completely resected completely and whose pathologic reports showed stage I or 0, was about 18 months to now.
The over-all result indicates some benefit from this preoperative chemotherapy and radiation therapeutic regimen in patients with advanced unresectable lung cancer.
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KEYWORD
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